The dynamic response of organisms exposed to environmental pathogens determines their
survival or demise, and the outcome of this interaction depends on the host’s susceptibility …

The prognosis of severe COVID-19 patients has motivated research communities to uncover
mechanisms of SARS-CoV-2 pathogenesis also on a regional level. In this work, we aimed …

The rise of multiresistant bacterial pathogens is currently one of the most critical threats to
global health, encouraging a better understanding of the evolution and spread of antimicrobial …

One of the approaches to address cancer treatment is to develop new drugs not only to obtain
compounds with less side effects, but also to have a broader set of alternatives to tackle …

The social amoeba Dictyostelium discoideum has proven to be a useful model for studying
relevant aspects of the host-pathogen interaction. In this work, D. discoideum was used as a …

The outcome of a host-pathogen interaction is determined by the conditions of the host, the
pathogen, and the environment. Although numerous proteomic studies of in vitro-grown …

Multiresistant and invasive hypervirulent Klebsiella pneumoniae strains have become one
of the most urgent bacterial pathogen threats. Recent analyses revealed a high genomic …

Background Pseudomonas aeruginosa is known to be a multidrug resistant opportunistic
pathogen. Particularly, P. aeruginosa PAO1 polyphosphate kinase mutant (ppk1) is deficient in …

The interest of the pharmaceutical industry in developing new antibiotics is decreasing, as
established screening systems which identify compounds that kill or inhibit the growth of …

Inorganic polyphosphate (polyP) deficiency in enteric bacterial pathogens reduces their ability
to invade and establish systemic infections in different hosts. For instance, inactivation of …