Phenobarbital is a central nervous system depressant that also indirectly activates nuclear
receptor constitutive active androstane receptor (CAR), which promotes drug and energy …

Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral
RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different …

Orai1 is a plasma membrane protein that in its tetrameric form is responsible for calcium influx
from the extracellular environment into the cytosol in response to interaction with the Ca 2…

The impact of mitochondrial dysfunction in epigenetics is emerging, but our understanding
of this relationship and its effect on gene expression remains incomplete. We previously …

Las1 is a recently discovered endoribonuclease that collaborates with Grc3–Rat1–Rai1 to
process precursor ribosomal RNA (rRNA), yet its mechanism of action remains unknown. …

Rix7 is an essential type II AAA-ATPase required for the formation of the large ribosomal
subunit. Rix7 has been proposed to utilize the power of ATP hydrolysis to drive the removal of …

The synthesis of eukaryotic ribosomes is a complex, energetically demanding process
requiring the aid of numerous non-ribosomal factors, such as the PeBoW complex. The …

Pulmonary epithelial injury is central to the pathogenesis of many lung diseases, such as
asthma, pulmonary fibrosis, and the acute respiratory distress syndrome. Regulated epithelial …

We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray
crystallography and functionally using fluorescence imaging. Crystallography and …

Botulism food poisoning is caused primarily by ingestion of the Clostridium botulinum
neurotoxin (BoNT). The 1300 amino acid BoNT forms a progenitor toxin (PTX) that, when …