User profiles for Mackenzie E. Chapman

Mackenzie Chapman

Purdue University
Verified email at purdue.edu
Cited by 1094

[HTML][HTML] Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

…, L Martinez-Sobrido, WC Liu, KM White, ME Chapman… - Nature, 2020 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics

…, M Brindisi, D Shahabi, ME Chapman… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …

Broad-spectrum inhibition of coronavirus main and papain-like proteases by HCV drugs

BJ Anson, ME Chapman, EK Lendy, S Pshenychnyi… - 2020 - researchsquare.com
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to over 200,000
deaths thus far. We screened a library of approved antiviral drugs against the two SARS-CoV-2 …

Structure-guided mutagenesis alters deubiquitinating activity and attenuates pathogenesis of a murine coronavirus

…, RC Mettelman, A O'Brien, ME Chapman… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses express a multifunctional papain-like protease, termed papain-like protease
2 (PLP2). PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a …

A structure-guided taxonomicbased approach to the design of broad-spectrum coronavirus protease inhibitors

…, EK Lendy, BJ Anson, ME Chapman… - … A Foundations and …, 2021 - journals.iucr.org
Human coronaviruses such as SARS-CoV, MERS and SARS-CoV-2 continue to emerge as
significant threats to public health. Other human coronaviruses such as NL63, HKU1, 229E …

Catalytic function and substrate specificity of alpha and beta coronavirus papain-like proteases: targeting human NL63, SARS-CoV and SARS-CoV-2 (Covid-19) with …

ME Chapman, CM Daczkowski, AK Ghosh… - Biophysical …, 2022 - ncbi.nlm.nih.gov
Mutations in estrogen receptor alpha (ERa), a nuclear transcription factor, are associated
with metastasis and poor disease-free survival of breast cancers patients. We isolated and …

Evaluation of Immune System Traits in Reciprocal Angus-Brahman F1 Crosses

MKG Chapman - 2022 - oaktrust.library.tamu.edu
… December 2022 Major Subject: Animal Science Copyright 2022 MacKenzie Gail Chapman
… Rob Chapman, and my brother Reece Chapman, for their support from 1,205 miles away. …

Estimating the prevalence of limb loss in the United States: 2005 to 2050

K Ziegler-Graham, EJ MacKenzie, PL Ephraim… - Archives of physical …, 2008 - Elsevier
Ziegler-Graham K, MacKenzie EJ, Ephraim PL, Travison TG, Brookmeyer R. Estimating the
prevalence of limb loss in the United States: 2005 to 2050. OBJECTIVE: To estimate the …

[BOOK][B] Complementary and alternative medicine for older adults: A guide to holistic approaches to healthy aging

ER Mackenzie, B Rakel - 2006 - books.google.com
Mackenzie completed her doctoral dissertation on health belief … Mackenzie currently teaches
courses on humanistic medicine in … a private practice with Cheryl Chapman in New Jersey. …

Geriatric assessment with management in cancer care: current evidence and potential mechanisms for future research

…, M Extermann, RL Olin, V Targia, A Mackenzie… - Journal of geriatric …, 2016 - Elsevier
Older adults with cancer represent a complex patient population. Geriatric assessment (GA)
is recommended to evaluate the medical and supportive care needs of this group. “GA with …