Introduction The secretion of trophic factors by mesenchymal stromal cells has gained increased
interest given the benefits it may bring to the treatment of a variety of traumatic injuries …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

The advances in cancer immunotherapy come with several obstacles, limiting its widespread
use and benefits so far only to a small subset of patients. One of the underlying challenges …

Gene therapies using adeno-associated viruses (AAVs) are among the most promising
strategies to treat or even cure hereditary and acquired retinal diseases. However, the …

Standardization is a method to provide guidance in a particular industry. It has a persistent
and often ambiguous influence on innovation. Standardization efforts are very different for …

Obesity and associated diseases, such as diabetes, have reached epidemic proportions
globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high …

3D cultures of human stem cell-derived hepatocyte-like cells (HLCs) have emerged as promising
models for short- and long-term maintenance of hepatocyte phenotype in vitro cultures …

Non-clinical models to study metabolism including animal models and cell assays are often
limited in terms of species translatability and predictability of human biology. This field …

Pancreatic in vitro research is of major importance to advance mechanistic understanding
and development of treatment options for diseases such as diabetes mellitus. We present a …

Disorders of the eye leading to visual impairment are a major issue that affects millions of
people. On the other side ocular toxicities were described for eg molecularly targeted therapies …