This study shows that spatial characterization can address the challenge of finding efficient
biomarkers, revealing that localization of macrophages and T cells in melanoma predicts …

Single-cell omics aim at charting the different types and properties of all cells in the human
body in health and disease. Over the past years, myriads of cellular phenotypes have been …

Single cell classification is elucidating homeostasis and pathology in tissues and whole
organs. We applied in situ spatial proteomics by multiplex antibody staining to routinely …

In situ multiplexing analysis and in situ transcriptomics are now providing revolutionary tools
to achieve the comprehension of the molecular basis of cancer and to progress towards …

Frailty is an age-related syndrome that exposes individuals to increased vulnerability. Although
it is potentially reversible, in most cases it leads to negative outcomes, including mortality…

Cyclic multiplex immunostaining consists of cycles of staining, imaging, removal of the
signal and repetition with another set of antibodies. Removal of the primary and secondary …

Reactivation of the anti-tumor response has shown substantial progress in aggressive tumors
such as melanoma and lung cancer. Data on less common histotypes are scanty. Immune …

Multiplexing, labeling for multiple immunostains in the very same cell or tissue section in situ,
has raised considerable interest. The methods proposed include the use of labeled primary …

Antigen masking in routinely processed tissue is a poorly understood process caused by
multiple factors. We sought to dissect the effect on antigenicity of each step of processing by …

Nephropathy represents a major complication of Fabry Disease and its accurate characterization
is of paramount importance in predicting the disease progression and assessing the …