Background Patients born outside the UK have contributed to a 20% rise in the UK's tuberculosis
incidence since 2000, but their effect on domestic transmission is not known. Here we …

Increasing knowledge about DosR regulon-encoded proteins has led us to produce novel
Mycobacterium tuberculosis antigens for immunogenicity testing in human populations in …

Background Tuberculosis elimination in countries with a low incidence of the disease
necessitates multiple interventions, including innovations in migrant screening. We examined a …

Background. An urgent UK investigation was launched to assess risk of invasive
Mycobacterium chimaera infection in cardiothoracic surgery and a possible association with …

Background The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is
increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of …

Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)–γ
response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK …

Background. BCG vaccination of infants is thought to provide good protection in all settings.
This study investigated whether Malawian infants made weaker responses across a cytokine …

Background Although BCG vaccination is recommended in most countries of the world, little
is known of the persistence of BCG-induced immune responses. As novel TB vaccines may …

IFNγ plays an important part in immunity to tuberculosis (TB), but although it is necessary, it is
not on its own sufficient for protection against TB. To identify other cytokines that play a role …

Background The incidence of TB has doubled in the last 20 years in London. A better
understanding of risk groups for recent transmission is required to effectively target interventions. …