User profiles for Magdalena I Ivanova

Magdalena Ivanova

Department of Neurology, University of Michigan
Verified email at umich.edu
Cited by 6008

Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology

MI Ivanova, Y Lin, YH Lee, J Zheng… - Biophysical chemistry, 2021 - Elsevier
Abnormal aggregation of proteins into filamentous aggregates commonly associates with
many diseases, such as Alzheimer’s disease, Parkinson’s disease and type-2 diabetes. These …

The structural biology of protein aggregation diseases: Fundamental questions and some answers

…, M Balbirnie, S Sambashivan, MI Ivanova… - Accounts of chemical …, 2006 - ACS Publications
Amyloid fibrils are found in association with at least two dozen fatal diseases. The tendency
of numerous proteins to convert into amyloid-like fibrils poses fundamental questions for …

Atomic structures of amyloid cross-β spines reveal varied steric zippers

MR Sawaya, S Sambashivan, R Nelson, MI Ivanova… - Nature, 2007 - nature.com
Amyloid fibrils formed from different proteins, each associated with a particular disease,
contain a common cross-β spine. The atomic architecture of a spine, from the fibril-forming …

Molecular tweezers: supramolecular hosts with broad-spectrum biological applications

…, I Siddique, R Malik, GR Linares, MI Ivanova… - Pharmacological …, 2023 - ASPET
Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a
remarkably broad spectrum of biologic activities. MTs act as inhibitors of the self-assembly …

Structure of the toxic core of α-synuclein from invisible crystals

JA Rodriguez, MI Ivanova, MR Sawaya, D Cascio… - Nature, 2015 - nature.com
The protein α-synuclein is the main component of Lewy bodies, the neuron-associated
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11-residue …

Molecular basis for insulin fibril assembly

MI Ivanova, SA Sievers, MR Sawaya… - Proceedings of the …, 2009 - National Acad Sciences
In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are
observed. We found that the segment of the insulin B-chain with sequence LVEALYL is the …

The 3D profile method for identifying fibril-forming segments of proteins

…, J Karanicolas, MI Ivanova… - Proceedings of the …, 2006 - National Acad Sciences
Based on the crystal structure of the cross-β spine formed by the peptide NNQQNY, we
have developed a computational approach for identifying those segments of amyloidogenic …

An amyloid-forming segment of β2-microglobulin suggests a molecular model for the fibril

MI Ivanova, MR Sawaya, M Gingery… - Proceedings of the …, 2004 - National Acad Sciences
In humans suffering from dialysis-related amyloidosis, the protein β2-microglobulin (β2M) is
deposited as an amyloid; however, an amyloid of β2M is unknown in mice. β2M sequences …

[HTML][HTML] A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

…, AG Fitzmaurice, R Lakshmanan, MI Ivanova… - …, 2012 - Springer
Aggregation of α-synuclein (α-syn) is implicated as being causative in the pathogenesis of
Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. Despite …

[HTML][HTML] Reduced lipid bilayer thickness regulates the aggregation and cytotoxicity of amyloid-β

…, R Zhang, M Dulchavsky, A Bhunia, MI Ivanova… - Journal of Biological …, 2017 - ASBMB
The aggregation of amyloid-β (Aβ) on lipid bilayers has been implicated as a mechanism by
which Aβ exerts its toxicity in Alzheimer's disease (AD). Lipid bilayer thinning has been …