Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of
neurodegenerative disorders. To identify new protein/pathway alterations and candidate …

Background Cerebrospinal fluid (CSF) has been used to identify biomarkers of neurological
disease. CSF protein biomarkers identified by high-throughput methods, however, require …

… Mahlon Collins was to furnish this and did so as long as he was with them. Each mo1'ning
he started on foot as the expedition broke camp, g·oj11g ahead along· a line agreed ltpon for …

Protein degradation is an essential biological process that regulates protein abundance
and removes misfolded and damaged proteins from cells. In eukaryotes, most protein …

Precise control of protein degradation is critical for life, yet how natural genetic variation
affects this essential process is largely unknown. Here, we developed a statistically powerful …

Amyotrophic lateral sclerosis (ALS) is the most common form of adult-onset motor neuron
disease. Heterogeneity in clinical, genetic, and pathological features of ALS suggest the …

RNA-binding protein pathology now represents one of the best characterized pathologic
features of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration patients …

The pathological accumulation of RNA-binding proteins (RBPs) within inclusion bodies is a
hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD…

The bulk of targeted cellular protein degradation is performed by the proteasome, a multi-subunit
11 complex consisting of the 19S regulatory particle, which binds, unfolds, and …

Protein degradation by the ubiquitin-proteasome system (UPS) is an essential biological
process 32 that regulates the abundance of cellular proteins and removes damaged and …