2-Bromohexadecanoic acid, or 2-bromopalmitate, was introduced nearly 50 years ago as a
nonselective inhibitor of lipid metabolism. More recently, 2-bromopalmitate re-emerged as a …

Objective Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during
diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been …

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is triggered by
metabolism of the sugar to increase ATP/ADP ratio that blocks the K ATP channel leading to …

Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation
of the joints and the presence of autoantibodies directed against proteins containing the …

Congenital generalized lipodystrophy (CGL), secondary to AGPAT2 mutation is characterized
by the absence of adipocytes and development of severe insulin resistance. In the current …

We recently showed that the anaplerotic enzyme pyruvate carboxylase (PC) is up-regulated
in human breast cancer tissue and its expression is correlated with the late stage of breast …

Acute fatty acid (FA) exposure potentiates glucose-stimulated insulin secretion in β cells
through metabolic and receptor-mediated effects. We assessed the effect of fatty acids on the …

Microfluidics is an enabling technology for both cell biology and chemical analysis. We
combine these attributes with a microfluidic device for on-line solid-phase extraction (SPE) and …

Macrophages are critical for the initiation and resolution of the inflammatory phase of wound
healing. In diabetes, macrophages display a prolonged inflammatory phenotype preventing …

Although visceral adipocytes located within the body’s central core are maintained at
approximately 37C, adipocytes within bone marrow, subcutaneous, and dermal depots are found …