Subtelomeric macrosatellite repeats are difficult to sequence using conventional sequencing
methods owing to the high similarity among repeat units and high GC content. Sequencing …

DNA sequence databases use compression such as gzip to reduce the required storage
space and network transmission time. We describe Nucleotide Archival Format (NAF)—a new …

Ebola virus ( EBOV ) is extremely virulent, and its glycoprotein is necessary for viral entry.
EBOV may adapt to its new host humans during outbreaks by acquiring mutations especially in …

Background Nearly all molecular sequence databases currently use gzip for data compression.
Ongoing rapid accumulation of stored data calls for a more efficient compression tool. …

Coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
encode a proofreading exonuclease, nonstructural protein 14 (nsp14), that helps ensure …

Background Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections
of mammalian germline cells. A large proportion of ERVs lose their open reading frames (…

Familial amyotrophic lateral sclerosis type 2 (ALS2) is a juvenile autosomal recessive motor
neuron disease caused by the mutations in the ALS2 gene. The ALS2 gene product, ALS2/…

Background Alopecia areata (AA) is considered a highly heritable, T-cell-mediated autoimmune
disease of the hair follicle. However, no convincing susceptibility gene has yet been …

Endogenous viral elements (EVEs) are viral sequences that are endogenized in the host cell.
Recently, several eukaryotic genomes have been shown to contain EVEs. To improve the …

The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species
transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host…