The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid
hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-…

Prime editing is a highly versatile CRISPR-based genome editing technology that works
without DNA double-strand break formation. Despite rapid technological advances, in vivo …

How cells adapt metabolism to meet demands is an active area of interest across biology.
Among a broad range of functions, the polyamine spermidine is needed to hypusinate the …

Competition for nutrients like glucose can metabolically restrict T cells and contribute to their
hyporesponsiveness during cancer. Metabolic adaptation to the surrounding …

Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of
disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in …

CD4 + T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic demands
of proliferation and effector function, and enforce specific transcriptional programmes 1 , …

Environmental microbial triggers shape the development and functionality of the immune
system. Alveolar macrophages (AMs), tissue-resident macrophages of the lungs, are in …

Adipose tissue (AT) plays a central role in systemic metabolic homeostasis, but its function
during bacterial infection remains unclear. Following subcutaneous bacterial infection, …

The thioredoxin-1 (Trx1) system is an important contributor to cellular redox balance and is
a sensor of energy and glucose metabolism. Here we show critical c-Myc-dependent …

Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has
been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is …