L1CAM is a transmembrane protein expressed on neurons that was presumed to be found
on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a panel …

Sensitive assays are essential for the accurate identification of individuals infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we report a multiplexed …

Extracellular vesicles (EVs) are released by all cells into biofluids and hold great promise as
reservoirs of disease biomarkers. One of the main challenges in studying EVs is a lack of …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected
over 21 million people worldwide since August 16, 2020. Compared to PCR and serology …

The COVID-19 pandemic has led to the rapid adoption of virtual clinic processes and healthcare
delivery. Herein, we examine the impact of virtualising genetics services at Canada’s …

By utilizing an integrated cell-free DNA approach, liquid biopsy shows earlier detection of
cancer in patients with LFS compared with current clinical surveillance methods such as …

Background COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral
flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-…

At least 5% of cancer diagnoses are attributed to a causal pathogenic or likely pathogenic
germline genetic variant (hereditary cancer syndrome—HCS). These individuals are …

Background Serological testing provides a record of prior infection with SARS-CoV-2, but
assay performance requires independent assessment. Methods We evaluated 3 commercial (…

The quantification and characterization of aggregated α-synuclein in clinical samples offer
immense potential toward diagnosing, treating, and better understanding neurodegenerative …