Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability
barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups) that regulate the …

Objectives To perform a systematic review and meta-analysis of genetic risk factors for age
at onset (AO) in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). …

Amyloidogenic protein aggregation is a hallmark of several human neurodegenerative
conditions, including Alzheimer’s, Parkinson’s, and Huntington’s disease (HD). Mutations and/or …

Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability
barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups) that regulate the …

INTRODUÇÃO: Embora o Zika Vírus (ZIKV) pareça ser proeminentemente neurotrópico,
existem alguns relatos do envolvimento de outros órgãos, particularmente o coração. Diante …

… type 3 de Mattos, Eduardo Preusser; Musskopf, Maiara Kolbe; Leotti, Vanessa Bielefeldt;
Saraiva… eduardo preusser de Mattos,1,2,3 Maiara Kolbe Musskopf,2 Vanessa Leotti Torman,4,5 …

… Steven Bergink, HH Kampinga, Maiara Kolbe Musskopf, Eduardo Preusser Mattos …

Active nuclear import of soluble cargo involves transport factors that shuttle cargo through
the nuclear pore complex (NPC) by binding to phenylalanine-glycine (FG) domains. How …

To address the mechanisms involved in GAA-trinucleotide expansion in Friedreich’s Ataxia (FRDA)
families, we are deepening two strictly related issues: 1) whether the GAA-expansion …

Selective transport through the nuclear pore complex (NPC) depends on the dynamic binding
of the intrinsically disordered components of the NPC, the FG-nups, with each other and …