Western blotting has been a key technique for determining the relative expression of
proteins within complex biological samples since the first publications in 1979. Recent …

The neuromuscular junction (NMJ) plays a fundamental role in transferring information from
lower motor neuron to skeletal muscle to generate movement. It is also an experimentally …

Introduction: Proteomic techniques offer insights into the molecular perturbations occurring
in muscular-dystrophies (MD). Revisiting published datasets can highlight conserved …

Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive
decline, and synaptic pathology contributes to disease pathophysiology. We recently observed …

The late 1970s saw the first publicly reported use of the western blot, a technique for
assessing the presence and relative abundance of specific proteins within complex biological …

Wallerian degeneration is an active program tightly associated with axonal degeneration,
required for axonal regeneration and functional recovery after nerve damage. Here we provide …

Synapses are an early pathological target in many neurodegenerative diseases ranging
from well-known adult onset conditions such as Alzheimer and Parkinson disease to …

Low levels of survival of motor neuron (SMN) protein cause the neuromuscular disease
spinal muscular atrophy (SMA), characterized by degeneration of lower motor neurons and …

Deafferentation of motor neurons as a result of defective sensory-motor connectivity is a critical
early event in the pathogenesis of spinal muscular atrophy, but the underlying molecular …

Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered
by compensatory or regenerative processes. In situations where axonal regeneration of …