A potent Th1 immune response is critical to the control of tuberculosis. The impact of an
additive Th2 response on the course of disease has so far been insufficiently characterized, …

The hallmark of pulmonary tuberculosis is the granuloma, which consists predominantly of
lymphocytes and macrophages and promotes immune-cell interaction with the causative …

Chimeric antigen receptor (CAR) redirected T cells are potent therapeutic options against
hematological malignancies. The current dominant manufacturing approach for CAR T cells …

ABSTRACT Information from comparative proteome analysis of Mycobacterium tuberculosis
and Mycobacterium bovis bacillus Calmette-Guérin (BCG) principally allows prediction of …

The hallmark of human Mycobacterium tuberculosis infection is the presence of lung granulomas.
Lung granulomas can have different phenotypes, with caseous necrosis and hypoxia …

Background Multiple genetic modifications may be required to develop potent off-the-shelf
chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases …

Aims: To determine the efficacy of room fumigation with vaporized hydrogen peroxide (VHP)
in decontamination of viable Mycobacterium tuberculosis. Methods and Results: About 8 × …

Background Detectable cytomegalovirus (CMV)-specific T cells in CMV-seronegative kidney
transplant recipients (KTRs) have been attributed to an absence of circulating antibodies …

Personalizing immunosuppression is a major objective in transplantation. Transplant
recipients are heterogeneous regarding their immunological memory and primary alloimmune …

Graft-versus-host disease (GVHD) is a major risk of the administration of allogeneic chimeric
antigen receptor (CAR)-redirected T cells to patients who are HLA unmatched. Gene editing …