A community-driven global reconstruction of human metabolism
Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus '…
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus '…
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …
framework for integrative analysis of experimental molecular systems biology data and …
Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome
Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as they …
cellular level. However, models of whole‐body metabolism have not been established as they …
[HTML][HTML] Membrane transporters in a human genome-scale metabolic knowledgebase and their implications for disease
Membrane transporters enable efficient cellular metabolism, aid in nutrient sensing, and
have been associated with various diseases, such as obesity and cancer. Genome-scale …
have been associated with various diseases, such as obesity and cancer. Genome-scale …
[HTML][HTML] Prediction of intracellular metabolic states from extracellular metabolomic data
MK Aurich, G Paglia, O Rolfsson, S Hrafnsdóttir… - Metabolomics, 2015 - Springer
Metabolic models can provide a mechanistic framework to analyze information-rich omics
data sets, and are increasingly being used to investigate metabolic alternations in human …
data sets, and are increasingly being used to investigate metabolic alternations in human …
[HTML][HTML] MetaboTools: a comprehensive toolbox for analysis of genome-scale metabolic models
MK Aurich, RMT Fleming, I Thiele - Frontiers in physiology, 2016 - frontiersin.org
Metabolomic data sets provide a direct read-out of cellular phenotypes and are increasingly
generated to study biological questions. Previous work, by us and others, revealed the …
generated to study biological questions. Previous work, by us and others, revealed the …
[HTML][HTML] Feature-based attention and the suppression of non-relevant object features
D Wegener, F Ehn, MK Aurich, FO Galashan… - Vision Research, 2008 - Elsevier
Feature-directed attention has been recently studied in various psychophysical,
electrophysiological, and imaging studies. Convincing evidence has been obtained for its global …
electrophysiological, and imaging studies. Convincing evidence has been obtained for its global …
Computational modeling of human metabolism and its application to systems biomedicine
MK Aurich, I Thiele - Systems medicine, 2016 - Springer
Modern high-throughput techniques offer immense opportunities to investigate whole-systems
behavior, such as those underlying human diseases. However, the complexity of the data …
behavior, such as those underlying human diseases. However, the complexity of the data …
When metabolism meets physiology: Harvey and Harvetta
Precision medicine is an emerging paradigm that requires realistic, mechanistic models
capturing the complexity of the human body. We present two comprehensive molecular to …
capturing the complexity of the human body. We present two comprehensive molecular to …
[HTML][HTML] Arterio-venous metabolomics exploration reveals major changes across liver and intestine in the obese Yucatan minipig
…, L Debrauwer, D Dardevet, I Thiele, MK Aurich… - Scientific Reports, 2019 - nature.com
Blood circulation mainly aims at distributing the nutrients required for tissue metabolism and
collecting safely the by-products of all tissues to be further metabolized or eliminated. The …
collecting safely the by-products of all tissues to be further metabolized or eliminated. The …