Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal adenocarcinoma (…

The factors necessary to maintain organ-specific progenitor cells are poorly understood and
yet of extreme clinical importance. Here, we identify the transcription factor SOX9 as the first …

We present genetic and biochemical evidence that PAX6 is a key regulator of pancreatic
islet hormone gene transcription and is required for normal islet development. In embryos …

Most insulin-producing β-cells in the fetal mouse pancreas arise during the secondary transition,
a wave of differentiation starting at embryonic day 13. Here, we show that disruption of …

One major unresolved question in the field of pancreas biology is whether ductal cells have
the ability to generate insulin-producing β-cells. Conclusive examination of this question has …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance. Here,
we examined the sensitivity of key islet-enriched transcription factors to oxidative stress, a …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding 1 . Translating these risk variants into mechanistic …

A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several
of which are known to control gene expression. The repertoire and regulation of lncRNAs …

Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration and
maintenance but also promotes development of hepatocellular carcinoma (HCC). Despite …

In the developing spinal cord, early progenitor cells of the oligodendrocyte lineage are
induced in the motor neuron progenitor (pMN) domain of the ventral neuroepithelium by the …