Salmonellae interplay with host cells
A Haraga, MB Ohlson, SI Miller - Nature Reviews Microbiology, 2008 - nature.com
Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …
the molecular mechanisms that underpin the interactions of salmonellae with their animal …
Innate immune response to Salmonella typhimurium, a model enteric pathogen
P Broz, MB Ohlson, DM Monack - Gut microbes, 2012 - Taylor & Francis
The innate immune system provides the first line of defense against invading microorganisms
by inducing a variety of inflammatory and antimicrobial responses. These responses are …
by inducing a variety of inflammatory and antimicrobial responses. These responses are …
[HTML][HTML] cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
KM Storek, NA Gertsvolf, MB Ohlson… - The Journal of …, 2015 - journals.aai.org
Type I IFN production is an important host immune response against viral and bacterial
infections. However, little is known about the ligands and corresponding host receptors that …
infections. However, little is known about the ligands and corresponding host receptors that …
[PDF][PDF] Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation
MB Ohlson, Z Huang, NM Alto, MP Blanc, JE Dixon… - Cell host & …, 2008 - cell.com
The Salmonella typhimurium type III secretion effector protein SifA is essential for inducing
tubulation of the Salmonella phagosome and binds the mammalian kinesin-binding protein …
tubulation of the Salmonella phagosome and binds the mammalian kinesin-binding protein …
[HTML][HTML] A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication
RB Richardson, MB Ohlson, JL Eitson, A Kumar… - Nature …, 2018 - nature.com
The endoplasmic reticulum (ER) is an architecturally diverse organelle that serves as a
membrane source for the replication of multiple viruses. Flaviviruses, including yellow fever virus, …
membrane source for the replication of multiple viruses. Flaviviruses, including yellow fever virus, …
SseJ Deacylase Activity by Salmonella enterica Serovar Typhimurium Promotes Virulence in Mice
MB Ohlson, K Fluhr, CL Birmingham… - Infection and …, 2005 - Am Soc Microbiol
Salmonella enterica serovar Typhimurium utilizes a type III secretion system (TTSS) encoded
on Salmonella pathogenicity island-2 (SPI2) to promote intracellular replication during …
on Salmonella pathogenicity island-2 (SPI2) to promote intracellular replication during …
[PDF][PDF] CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
the causative virus in the COVID-19 pandemic, host ribosomes undergo …
the causative virus in the COVID-19 pandemic, host ribosomes undergo …
[HTML][HTML] FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms
…, NUN Nguyen, JL Eitson, MB Ohlson… - Biomedicine & …, 2023 - Elsevier
The continuing heavy toll of the COVID-19 pandemic necessitates development of therapeutic
options. We adopted structure-based drug repurposing to screen FDA-approved drugs for …
options. We adopted structure-based drug repurposing to screen FDA-approved drugs for …
Phase 2 randomized trial of the safety and efficacy of MHAA4549A, a broadly neutralizing monoclonal antibody, in a human influenza A virus challenge model
…, D Nazzal, CM Rosenberger, MB Ohlson… - Antimicrobial agents …, 2017 - Am Soc Microbiol
MHAA4549A, a human monoclonal antibody targeting the hemagglutinin stalk region of
influenza A virus (IAV), is being developed as a therapeutic for patients hospitalized with severe …
influenza A virus (IAV), is being developed as a therapeutic for patients hospitalized with severe …
A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection
DB Heisler, KA Johnson, DH Ma, MB Ohlson, L Zhang… - Elife, 2023 - elifesciences.org
Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered through
interactions with phospholipids and transmembrane domains of proteins. However, as …
interactions with phospholipids and transmembrane domains of proteins. However, as …