[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

…, G Piumatti, GL Presti, AF Pellanda, M Biggiogero… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …

[HTML][HTML] Neutralization, effector function and immune imprinting of Omicron variants

…, P Ferrari, A Franzetti-Pellanda, M Biggiogero… - Nature, 2023 - nature.com
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain 1 (RBD) of the spike protein. The effects of these mutations …

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

…, R Cacciatore, T Terrot, AF Pellanda, M Biggiogero… - Science, 2021 - science.org
The identification of CD4 + T cell epitopes is instrumental for the design of subunit vaccines
for broad protection against coronaviruses. Here, we demonstrate in COVID-19–recovered …

[HTML][HTML] Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

…, AA Shanbhag, M Matkovic, M Biggiogero… - Nature …, 2023 - nature.com
Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse
symptoms, which can persist for months. While antiviral antibodies are protective, those targeting …

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

…, M Matkovic, C Toscano, M Biggiogero… - Science …, 2023 - science.org
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development …

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

…, P Ferrari, A Franzetti-Pellanda, M Biggiogero… - Biorxiv, 2023 - biorxiv.org
Currently circulating SARS-CoV-2 variants acquired convergent mutations at receptor-binding
domain (RBD) hot spots 1 . Their impact on viral infection, transmission, and efficacy of …

[PDF][PDF] Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

…, T Terrot, V Lepori, M Tarkowski, A Riva, M Biggiogero… - Iscience, 2023 - cell.com
Memory B cells (MBCs) generate rapid antibody responses upon secondary encounter with
a pathogen. Here, we investigated the kinetics, avidity, and cross-reactivity of serum …

Toxic effects of two pesticides, Imazalil and Triadimefon, on the early development of the ascidian Phallusia mammillata (Chordata, Ascidiacea)

R Pennati, S Groppelli, G Zega, M Biggiogero… - Aquatic toxicology, 2006 - Elsevier
Azole compounds are fungicides used in agriculture and in clinical area and are suspected
to produce craniofacial malformations in vertebrates. Toxicity tests on sperm viability, …

Developmental expression of glutamic acid decarboxylase and of γ‐aminobutyric acid type B receptors in the ascidian Ciona intestinalis

G Zega, M Biggiogero, S Groppelli… - Journal of …, 2008 - Wiley Online Library
We describe Ciona intestinalis γ‐aminobutyric acid (GABA)‐ergic neurons during
development, studying the expression pattern of Ci‐GAD (glutamic acid decarboxylase: GABA …

[HTML][HTML] Nasogastric tube in mechanical ventilated patients: ETCO2 and pH measuring to confirm correct placement. A pilot study

…, F Ruggiero, G Bona, A Glotta, M Biggiogero… - Plos one, 2022 - journals.plos.org
Introduction Nasogastric tube (NGT) placement is a procedure commonly performed in
mechanically ventilated (MV) patients. Chest X-Ray is the diagnostic gold-standard to confirm its …