Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive
neurological disorder characterized by early-onset sensorineural deafness and brain …

Scribble (Scrib) is a key regulator of apicobasal polarity, presynaptic architecture, and short-term
synaptic plasticity in Drosophila. In mammals, its homolog Scrib1 has been implicated …

The appropriate trafficking of glutamate receptors to synapses is crucial for basic synaptic
function and synaptic plasticity. It is now accepted that NMDA receptors (NMDARs) internalize …

Neurodevelopmental disorders arise from combined defects in processes including cell
proliferation, differentiation, migration and commissure formation. The evolutionarily conserved …

Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain
development; whether it plays specific roles at postnatal stages remains rather unknown. …

Core planar cell polarity (PCP) genes, which are involved in various neurodevelopmental
disorders such as neural tube closure, epilepsy, and autism spectrum disorder, have poorly …

Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are
essential for axon outgrowth and guidance. Whether planar cell polarity (PCP) proteins, which …

Scribble (Scrib) is a conserved polarity protein acting as a scaffold involved in multiple
cellular and developmental processes. Recent evidence from our group indicates that Scrib is …

In this chapter, we focus on inherited or de novo human mutations associated with autism
spectrum disorder (ASD) or intellectual disability (ID) disorder, which involve members of the …

The organization of spatial information, including pattern completion and pattern separation
processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms …