Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important
environmental factors for myopia control. Here we show that violet light (VL, 360–400nm …

Despite the global pandemic of myopia, the precise molecular mechanism of the onset of
myopia remains largely unknown. This is partially because of the lack of efficient murine …

Medullary thymic epithelial cells (mTECs) expressing the autoimmune regulator AIRE and
various tissue-specific antigens (TSAs) are critical for preventing the onset of autoimmunity …

Medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (Aire) are
critical for preventing the onset of autoimmunity. However, the differentiation program of Aire-…

The environment experienced during spaceflight may impact the immune system and the
thymus appears to undergo atrophy during spaceflight. However, molecular aspects of this …

The translational regulation of maternal mRNAs is one of the most important steps in the control
of temporal–spatial gene expression during oocyte maturation and early embryogenesis …

Increased global incidence of myopia necessitates establishment of therapeutic approaches
against its progression. To explore agents which may control myopia, we screened 207 …

Virus-derived double-stranded RNAs (dsRNAs) are sensed in the cytosol by retinoic acid-inducible
gene (RIG)-I-like receptors (RLRs). These induce the expression of type I IFN and …

Medullary thymic epithelial cells (mTECs) are critical for self-tolerance induction in T cells
via promiscuous expression of tissue-specific antigens (TSAs), which are controlled by the …

Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial damage.
However, stress-independent autophagy is activated by unclear mechanisms in several …