An in vitro drug-induced cardiotoxicity assay is a critical step in drug discovery for clinical
use. The use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is …

Despite major therapeutic advances, heart failure, as a non-communicable disease, remains
a life-threatening disorder, with 26 million patients worldwide, causing more deaths than …

Although engineered cardiac tissues (ECTs) derived from induced pluripotent stem cells (iPSCs)
are promising for myocardial regenerative therapy, the appropriate ratio of …

Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic
cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, …

Transplantation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells
(hiPSC-CMs) is a promising treatment for heart failure, but residual undifferentiated hiPSCs …

Objective Reversible/irreversible abnormalities of regional cerebral blood flow (rCBF) are
seen in patients with depression. However, in late‐life depression there is little evidence of a …

Desmoglein-2, encoded by DSG2, is one of the desmosome proteins that maintain the
structural integrity of tissues, including heart. Genetic mutations in DSG2 cause arrhythmogenic …

Background Although implantation of a left ventricular assist device (LVAD) induces reverse
remodeling of the left ventricle in end-stage nonischemic dilated cardiomyopathy (DCM), the …

Purpose. The role of nitric oxide in the development of selenite-induced cataracts in rats was
examined using nitric oxide synthase (NOS) inhibitors. Methods. Subcutaneous injection of …

Background: The Δ160E mutation in TNNT2, which encodes troponin T, is a rare pathogenic
variant identified in patients with hypertrophic cardiomyopathy and is associated with poor …