Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior

…, JA Cooper, MR Nuutinen… - Proceedings of the …, 2018 - National Acad Sciences
We are presented with choices each day about how to invest our effort to achieve our goals.
Critically, these decisions must frequently be made under conditions of incomplete …

[HTML][HTML] Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

JA Cooper, MR Nuutinen, VM Lawlor… - Nature …, 2021 - nature.com
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet
the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-…

Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala

…, JA Cooper, BAM DeVries, MR Nuutinen… - Molecular …, 2023 - nature.com
Stress is known to be a significant risk factor for the development of Major Depressive
Disorder (MDD), yet the neural mechanisms that underlie this risk are poorly understood. Prior …

Glutamatergic adaptation to stress in medial prefrontal cortex underlies risk and resilience for pessimistic beliefs

JA Cooper, MR Nuutinen, VM Lawlor, BAM DeVries… - bioRxiv, 2020 - biorxiv.org
Stress is a major risk factor for the development of mental illness, including major depressive
disorder (MDD), yet the underlying biological mechanisms remain unclear. Particular …

Dual Process Theory and the Political Belief Bias Effect

MR Nuutinen, DG Wendell, RE Matland, RG Morrison - researchgate.net
● Decades of research in thinking and reasoning suggests that two competing systems are
frequently engaged to make decisions (Kahneman, 2011).● Dual Process Theory (Evans, …

A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation

…, S Liu, A Arulpragasam, B DeVries, N Irfan, M Nuutinen… - 2024 - researchsquare.com
Chronic, low-grade inflammation has been associated with motivational deficits in patients
with major depression (MD). In turn, impaired motivation has been linked to poor quality of life …

P216. Effects of Acute Stress on Dorsal Anterior Cingulate Encoding of Expected Value in MDD

…, B DeVries, M Nuutinen… - Biological …, 2022 - biologicalpsychiatryjournal.com
Background Stress is a major risk factor for depression and is known to alter cortostriatal
networks critical for reinforcement learning. To date, however, the specific computational …

[PDF][PDF] 18.1 Electroencephalographic Oscillations as Biomarkers of Emerging Psychosis During Adolescence

INATR OFFSPRING - Journal of the American Academy of Child & …, 2016 - academia.edu
Conclusions: Together, these studies demonstrate that diagnoses such as SZ and BD, and
their clinical features, are increasingly predictable with neurodevelopmental indicators. …

[HTML][HTML] PNAS PLUS

CT Johnson, JA Wroe, R Agarwal, KE Martin… - PNAS, 2018 - ncbi.nlm.nih.gov
Orthopedic implant infections require long-term antibiotic therapy and surgical debridement
to successfully retain the implant; however, therapeutic failure can lead to implant removal. …

[HTML][HTML] Understanding the neurodynamic process of decision-making for mobile application downloading

H Parmar, F Davis, E Walden - Plos one, 2022 - journals.plos.org
In this article, we try to explore and understand the neurodynamics of the decision-making
process for mobile application downloading. We begin the model development in a rather …