An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity
C Motozono, M Toyoda, J Zahradnik, T Ikeda, A Saito… - BioRxiv, 2021 - biorxiv.org
During the current SARS-CoV-2 pandemic that is devastating the modern societies
worldwide, many variants that naturally acquire multiple mutations have emerged. Emerging …
worldwide, many variants that naturally acquire multiple mutations have emerged. Emerging …
Virological characteristics of SARS-CoV-2 BA. 2 variant
…, Y Kosugi, K Kobiyama, T Hara, M Toyoda… - BioRxiv, 2022 - biorxiv.org
Soon after the emergence and global spread of a new severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) Omicron lineage, BA.1 (ref 1 , 2 ), another Omicron lineage, BA.2…
coronavirus 2 (SARS-CoV-2) Omicron lineage, BA.1 (ref 1 , 2 ), another Omicron lineage, BA.2…
SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by multiple
spike mutations across all spike domains. Here we show that Omicron BA.1 has higher …
spike mutations across all spike domains. Here we show that Omicron BA.1 has higher …
[HTML][HTML] The SARS-CoV-2 Omicron BA. 1 spike G446S mutation potentiates antiviral T-cell recognition
C Motozono, M Toyoda, TS Tan, H Hamana… - Nature …, 2022 - nature.com
Although the Omicron variant of the SARS-CoV-2 virus shows resistance to neutralizing
antibody, it retains susceptibility to the cellular immune response. Here we characterize vaccine-…
antibody, it retains susceptibility to the cellular immune response. Here we characterize vaccine-…
Differential ability of primary HIV-1 Nef isolates to downregulate HIV-1 entry receptors
M Toyoda, Y Ogata, M Mahiti, Y Maeda… - Journal of …, 2015 - Am Soc Microbiol
HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors CCR5 and
CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral replication …
CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral replication …
[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
[PDF][PDF] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
C Motozono, M Toyoda, J Zahradnik, A Saito… - Cell host & …, 2021 - cell.com
Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These
mutations can affect viral properties such as infectivity and immune resistance. Although the …
mutations can affect viral properties such as infectivity and immune resistance. Although the …
[PDF][PDF] Virological characteristics of the SARS-CoV-2 Omicron BA. 2 spike
…, Y Kosugi, K Kobiyama, T Hara, M Toyoda… - Cell, 2022 - cell.com
Soon after the emergence and global spread of the SARS-CoV-2 Omicron lineage BA.1,
another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis …
another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis …
[PDF][PDF] Natural HIV-1 Nef polymorphisms impair SERINC5 downregulation activity
HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5;
however, the impact of natural Nef polymorphisms on this function is largely unknown. We …
however, the impact of natural Nef polymorphisms on this function is largely unknown. We …
[HTML][HTML] SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion
The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by
multiple spike mutations across all spike domains. Here we show that compared to the Delta …
multiple spike mutations across all spike domains. Here we show that compared to the Delta …