User profiles for Makoto Arai

Makoto Arai

Chiba University
Verified email at umin.ac.jp
Cited by 7904

Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease

H Sumi, O Yokosuka, N Seki, M Arai, F Imazeki… - Hepatology, 2003 - Elsevier
To investigate the hepatitis B virus (HBV) genotype-related differences in the progression of
liver disease, 585 patients with chronic HBV infection including 258 with histologically …

Structure of pathological TDP-43 filaments from ALS with FTLD

D Arseni, M Hasegawa, AG Murzin, F Kametani, M Arai… - Nature, 2022 - nature.com
The abnormal aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in neurons and glia
is the defining pathological hallmark of the neurodegenerative disease amyotrophic lateral …

Brain cannabinoid CB2 receptor in schizophrenia

…, ES Onaivi, H Kunugi, T Sasaki, M Itokawa, M Arai… - Biological …, 2010 - Elsevier
BACKGROUND: Neural endocannabinoid function appears to be involved in schizophrenia.
Two endocannabinoid receptors, CB1 and CB2, are found in the brain and elsewhere in the …

[PDF][PDF] Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights

…, J Egawa, A Nunokawa, M Itokawa, M Arai… - Cell reports, 2018 - cell.com
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs)
in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …

Subthalamic deep brain stimulation can improve gastric emptying in Parkinson's disease

E Arai, M Arai, T Uchiyama, Y Higuchi, K Aoyagi… - Brain, 2012 - academic.oup.com
It is established that deep brain stimulation of the subthalamic nucleus improves motor
function in advanced Parkinson’s disease, but its effects on autonomic function remain to be …

Enhanced carbonyl stress in a subpopulation of schizophrenia

M Arai, H Yuzawa, I Nohara, T Ohnishi… - Archives of general …, 2010 - jamanetwork.com
Context Various factors are involved in the pathogenesis of schizophrenia. Accumulation of
advanced glycation end products, including pentosidine, results from carbonyl stress, a state …

Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia

…, H Ishiguro, S Yazaki, Y Horiuchi, M Arai… - Human molecular …, 2009 - academic.oup.com
Chromatin remodeling may play a role in the neurobiology of schizophrenia and the process,
therefore, may be considered as a therapeutic target. The SMARCA2 gene encodes BRM …

Randomized phase II trial comparing site-specific treatment based on gene expression profiling with carboplatin and paclitaxel for patients with cancer of unknown …

H Hayashi, T Kurata, Y Takiguchi, M Arai… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE Although gene expression profiling is a promising diagnostic technique to
determine the tissue of origin for patients with cancer of unknown primary site (CUP), no clinical …

Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis

Y Akagi, Y Isaka, M Arai, T Kaneko, M Takenaka… - Kidney international, 1996 - Elsevier
glomerulonephritis Page 1 Kidney International, Vol. 50 (1996), pp. 148–155 Inhibition of
TGF-81 expression by antisense oligonucleotides suppressed extracellular matrix …

[HTML][HTML] Evidence-based clinical practice guidelines for functional dyspepsia 2021

H Miwa, A Nagahara, A Asakawa, M Arai… - Journal of …, 2022 - Springer
Background Functional dyspepsia (FD) is a disorder that presents with chronic dyspepsia,
which is not only very common but also highly affects quality of life of the patients. In Japan, …