A desired goal of targeted cancer treatments is to achieve high tumor specificity with minimal
side effects. Despite recent advances, this remains difficult to achieve in practice as most …

Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without
need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The …

A chelation-enhanced fluorescence method for the detection of paramagnetic copper(II) ions
is developed. Two dyes with unequal metal ion binding constants are used, each giving …

Hydrogen sulfide (H2S) is an important biomolecule with high therapeutic potential. Here
we leverage the inverse-electron demand Diels–Alder (IEDDA) click reaction between a …

Labeling a protein of interest (POI) with a fluorescent reporter is a powerful strategy for studying
protein structures and dynamics in their native environments. Compared to fluorescent …

Dihydrogen sulfide recently emerged as a biological signaling molecule with important
physiological roles and significant pharmacological potential. Chemically plausible explanations …

Described is a scalable procedure for driving photochemical sytheses of trans-cyclooctene
derivatives through metal complexation. During photoirradiation, reaction mixtures are …

A new, highly sensitive fluorescent sensor for Zn(II) ion (a tris(2-pyridylmethyl)amine
derivative) shows very strong binding and Zn(II) concentration-dependent biexponential time-…

The ability to activate drugs only at desired locations avoiding systemic immunosuppression
and other dose limiting toxicities is highly desirable. Here we present a new approach, …

A novel methodology for the synthesis of poly(ethylene glycol) (PEG) prodrugs of amino-containing
compounds has been developed which is based on the trimethyl lock lactonization …