Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Based on recent molecular genetics, as well as functional and quantitative anatomical
studies, the basal forebrain (BF) cholinergic projections, once viewed as a diffuse system, are …

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Methamphetamine (MA) addiction is a growing epidemic worldwide. Chronic MA use has
been shown to lead to neurotoxicity in rodents and humans. Magnetic resonance imaging (MRI…

The ability to map the functional connectivity of discrete cell types in the intact mammalian
brain during behavior is crucial for advancing our understanding of brain function in normal …

Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging
have been reported in obese humans and rodents. Similar deficits have been reported in …

Methylphenidate (MP) is a psychostimulant widely prescribed to treat Attention Deficit
Hyperactivity Disorder (ADHD). Although generally well tolerated, growth deficits have been …

Previously, we created an 8-h limited-access dual bottle drinking paradigm to deliver
methylphenidate (MP) to rats at two dosages that result in a pharmacokinetic profile similar to …

Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
p ) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using …

Purpose To determine if one venous blood sample can substitute full arterial sampling in
quantitative modeling for multiple positron emission tomography (PET) radiotracers using …