▪ Abstract Receptors for the Fc domain of immunoglobulins play an important role in immune
defense. There are two well-defined functional classes of mammalian receptors. One class …

Revised Manuscript ReceivedSeptember 5, 1995® abstract: The neonatal Fc receptor (FcRn)
binds maternal immunoglobulin G (IgG) from ingested milk in the gut (pH 6.0—6.5) and …

Calreticulin is a calcium-binding chaperone that has several functions in the immune
response. In the endoplasmic reticulum (ER), calreticulin facilitates the folding of major …

The neonatal Fc receptor (FcRn) is structurally similar to class I major histocompatibility
molecules. FcRn transports maternal immunoglobulin G (IgG) from ingested milk into the blood. …

The assembly of major histocompatibility complex (MHC) class I molecules with peptides is
orchestrated by several assembly factors including the transporter associated with antigen …

MATERIALS AND METHODS Reagents. Centricon-10 ultrafiltration units were obtained
from Amicon (Beverly, MA). CNBr-activated Sepharose for affinity column preparation, a …

A number of immunological functions are ascribed to cell surface-expressed forms of the
endoplasmic reticulum (ER) chaperone calreticulin (CRT). In this study, we examined the …

MHC class I polymorphisms are known to influence outcomes in a number of infectious
diseases, cancers, and inflammatory diseases. Human MHC class IH chains are encoded by the …

Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the
absence of tapasin, an essential component of the peptide loading complex. We quantified …

The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …