There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors
in age-related macular degeneration and subtypes of retinitis pigmentosa. Human …

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but
it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. …

Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular
toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology …

The highly regenerative capacity of the human adult oral mucosa suggests the existence of
a robust stem cell (SC) population in its lamina propria (OMLP). The purpose of this study …

Hundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can
be induced through the activity of just a small number of core TFs. Systematic identification of …

Gliomas express many genes that play a role in neural precursor cells (NPCs), but no direct
comparison between glioma and stem cell (SC) gene expression profiles has been …

Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …

Embryonic development is a complex process that is unamenable to direct observation. In
this study, we implanted a window to the mouse uterus to visualize the developing embryo …

Variable levels of DNA methylation have been reported at tissue-specific differential methylation
regions (DMRs) overlapping enhancers, including super-enhancers (SEs) associated …