Various animals across the tree of life express some form of programmed dormancy (eg
hibernation, diapause) to maximize fitness in highly seasonal environments. The integrated …

Brown adipose tissue (BAT) is a unique thermogenic tissue in mammals that rapidly produces
heat via nonshivering thermogenesis. Small mammalian hibernators have evolved the …

Changes in cis-regulatory regions are thought to play a major role in the genetic basis of
adaptation. However, few studies have linked cis-regulatory variation with adaptation in natural …

Distinguishing between genetic, environmental, and genotype × environment effects is
central to understanding geographic variation in phenotypic clines. Two of the best-documented …

Changes in gene expression are thought to play a major role in adaptive evolution. While it
is known that gene expression is highly sensitive to the environment, very few studies have …

Changes in gene regulation have long been appreciated as a driving force of adaptive
evolution, however the relative contributions of cis- and trans-acting changes to gene regulation …

The laboratory mouse has served as the premier animal model system for both basic and
preclinical investigations for over a century. However, laboratory mice capture only a subset of …

Brown adipose tissue (BAT) is a thermogenic organ that is vital for hibernation in mammals.
Throughout the hibernation season, BAT mitochondrial uncoupling protein 1 (UCP1) …

During hibernation, thirteen-lined ground squirrels (Ictidomys tridecemlineatus) regularly
cycle between bouts of torpor and interbout arousal (IBA). Most of the brain is electrically …

Understanding the genetic basis of environmental adaptation in natural populations is a central
goal in evolutionary biology. The conditions at high elevation, particularly the low oxygen …