DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development.
In a computational search for enzymes that could modify 5-methylcytosine (5mC), we …

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine
(5hmC) in DNA 1 , 2 . The gene encoding TET2 resides at chromosome …

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell
types in mammals 1 , 2 , 3 , 4 , 5 . 5hmC is generated by the TET family of Fe(II) and 2-…

TET family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in
DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain …

Background We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine
(5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and …

NFAT transcription factors are highly phosphorylated proteins that are regulated by the
calcium-dependent phosphatase calcineurin. We show by mass spectrometry that NFAT1 is …

Gene transcription is critically influenced by chromatin structure and the modification status
of histone tails 1 . Methylation of lysine residues in histone tails is dynamically regulated by …

Modified bases in nucleic acids present a layer of information that directs biological function
over and beyond the coding capacity of the conventional bases. While a large number of …

Phosphoinositides play important roles in regulating the cytoskeleton and vesicle trafficking,
potentially important processes at the cleavage furrow. However, it remains unclear which, if …

The Tet family of methylcytosine dioxygenases (Tet1, Tet2, and Tet3) convert 5-methylcytosine
to 5-hydroxymethylcytosine. To date, functional overlap among Tet family members has …