Highly infectious illness caused by pathogens is endemic especially in developing nations
where there is limited laboratory infrastructure and trained personnel. Rapid point-of-care (…

Metagenomic next-generation sequencing (mNGS), the shotgun sequencing of RNA and
DNA from clinical samples, has proved useful for broad-spectrum pathogen detection and the …

Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in
newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV-…

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here,
we found that 26% of nonhuman primates infected with Asian/American ZIKV in early …

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency
and resultant hyperglycemia. Complex interactions of genetic and environmental factors …

During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly
shown to cause fetal loss and congenital malformations in acutely and chronically infected …

A monkey model of Zika virus (ZIKV) infection is urgently needed to better understand
transmission and pathogenesis, given its proven association with fetal brain defects in pregnant …

Stress granules (SGs) are highly dynamic cytoplasmic foci that form in response to activation
of the integrated stress response (ISR) that results in eIF2α phosphorylation and global …

Background Currently, no FDA-approved vaccines or treatments are available for Ebola
virus disease (EVD), and therapy remains largely supportive. Ebola virus (EBOV) has broad …

Viral outbreaks can cause widespread disruption, creating the need for diagnostic tools that
provide high performance and sample versatility at the point of use with moderate complexity…