DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus
…, P Möller, AJ Rennekamp, M Krumbiegel… - Journal of …, 2004 - Am Soc Microbiol
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of
pathogens interacting with these attachment factors is incompletely defined. Here we show that …
pathogens interacting with these attachment factors is incompletely defined. Here we show that …
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble …
H Hofmann, M Geier, A Marzi, M Krumbiegel… - Biochemical and …, 2004 - Elsevier
The angiotensin converting enzyme 2 (ACE2) has been identified as a receptor for the
severe acute respiratory syndrome associated coronavirus (SARS-CoV). Here we show that …
severe acute respiratory syndrome associated coronavirus (SARS-CoV). Here we show that …
S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected …
…, A Marzi, T Gramberg, M Geier, M Krumbiegel… - Journal of …, 2004 - Am Soc Microbiol
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes severe
pneumonia with a fatal outcome in approximately 10% of patients. SARS-CoV is not closely …
pneumonia with a fatal outcome in approximately 10% of patients. SARS-CoV is not closely …
[HTML][HTML] LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus
…, P Möller, PF Lalor, A Marzi, M Geier, M Krumbiegel… - Virology, 2005 - Elsevier
Cellular attachment factors like the C-type lectins DC-SIGN and DC-SIGNR (collectively
referred to as DC-SIGN/R) can augment viral infection and might promote viral dissemination in …
referred to as DC-SIGN/R) can augment viral infection and might promote viral dissemination in …
Diagnostic yield and novel candidate genes by exome sequencing in 152 consanguineous families with neurodevelopmental disorders
Importance Autosomal recessive inherited neurodevelopmental disorders are highly
heterogeneous, and many, possibly most, of the disease genes are still unknown. Objectives To …
heterogeneous, and many, possibly most, of the disease genes are still unknown. Objectives To …
[HTML][HTML] Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
…, K Kahrizi, VM Kalscheuer, A Kan, M Krumbiegel… - Nature, 2023 - nature.com
Thousands of genetic variants in protein-coding genes have been linked to disease.
However, the functional impact of most variants is unknown as they occur within intrinsically …
However, the functional impact of most variants is unknown as they occur within intrinsically …
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
…, F Krach, M Krumbiegel… - Proceedings of the …, 2018 - National Acad Sciences
α-Synuclein (α-Syn) aggregation, proceeding from oligomers to fibrils, is one central
hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are toxic by triggering …
hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are toxic by triggering …
Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS
S Carl, TC Greenough, M Krumbiegel… - Journal of …, 2001 - Am Soc Microbiol
The human immunodeficiency virus type 1 (HIV-1) Nef protein has several independent
functions that might contribute to efficient viral replication in vivo. Since HIV-1 adapts rapidly to …
functions that might contribute to efficient viral replication in vivo. Since HIV-1 adapts rapidly to …
Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2
…, MP Lux, PA Fasching, M Krumbiegel… - … journal of cancer, 2017 - Wiley Online Library
Breast and ovarian cancer (BC/OC) predisposition has been attributed to a number of high‐
and moderate to low‐penetrance susceptibility genes. With the advent of next generation …
and moderate to low‐penetrance susceptibility genes. With the advent of next generation …
[HTML][HTML] Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
F Pasutto, M Krumbiegel, CY Mardin… - … & visual science, 2008 - iovs.arvojournals.org
purpose. Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were
recently associated with both pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (…
recently associated with both pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (…