Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative
treatments. Considering its environmental cause, we hypothesized that COPD will be …

Airway epithelial cells reduce cytosolic ATP content in response to treatment with S. aureus
alpha-toxin (hemolysin A, Hla). This study was undertaken to investigate whether this is due …

Glioblastoma is a common, malignant brain tumor whose disease incidence increases with
age. Glioblastoma stem-like cells (GSCs) are thought to contribute to cancer therapy …

Activin A is a multifunctional growth and differentiation factor with pronounced neuroprotective
properties that is strongly up-regulated in various forms of acute brain disorders and …

Angiogenesis due to hypoxic-ischemic (HI) injury represents a crucial compensatory
mechanism of the developing brain that is mainly regulated by hypoxia-inducible transcription …

Complexity of lung microenvironment and changes in cellular composition during disease
make it exceptionally hard to understand molecular mechanisms driving development of …

Purpose Brain metastasis formation is a rare and late event in colorectal cancer (CRC) patients
and associated with poor survival. In contrast to other metastatic sites, the knowledge on …

Background Dysregulated innate immune signaling has been identified as a driver of the
complex pathophysiology of myelodysplastic syndromes (MDS), predominantly in low risk (LR)-…

Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative
treatments. Considering the environmental cause of COPD (eg, cigarette smoke) and disease …

Background Microglial activation due to a variety of stimuli induces secretion of neurotoxic
substances including inflammatory cytokines and nitric oxide (NO). Clinical studies indicate a …