Most large-scale production processes in biotechnology are performed in fed-batch operational
mode. In contrast, the screenings for microbial production strains are run in batch mode, …

Background Chimeric virus-like particles (VLP) allow the display of foreign antigens on their
surface and have proved valuable in the development of safe subunit vaccines or drug …

An Arxula adeninivorans integration vector was applied to a range of alternative yeast
species including Saccharomyces cerevisiae, Debaryomyces hansenii, Debaryomyces …

The strength and regulatory characteristics of the heat-inducibleHSA1, HSA2 andTPS1
promoters were compared with those of the well-established, carbon source-regulatedFMD …

A vaccine to prevent hepatitis C virus (HCV) infection is urgently needed for use alongside
direct-acting antiviral drugs to achieve elimination targets. We have previously shown that a …

The bZIP regions of the eukaryotic transcription factors GCN4 and C/EBP have similar
protein sequences but they recognize different DNA sequences. In order to understand their …

The development of effective malaria vaccines remains a global health priority. Currently, the
most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. …

The early status of strain development for the production of interleukin (IL)-6, IL-8, IL-10, and
interferon (IFN) γ is described. The general approach to generating such strains was to …

Two residues are invariant in all bZip basic regions: asparagine –18 and arginine –10 (we
define the first leucine of the leucine zipper of GCN4 as +1). X-ray structures of two specific …

Ectoine and 5-hydroxyectoine belong to the family of compatible solutes which are known to
mainly contribute to the adaptation of the cell to osmotic stress by mediation of a constant …