We have developed an algorithm for identifying proteins at the sub-microgram level without
sequence determination by chemical degradation. The protein, usually isolated by one- or …

Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β),
inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1β, little …

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic
physiology across most living organisms. Although such rhythms have been extensively …

Faithful cell-cycle progression is tightly controlled by the ubiquitin-proteasome system. Here
we identify a human Cullin 3-based E3 ligase (Cul3) which is essential for mitotic division. In …

We describe a method for comparative quantitation and de novo peptide sequencing of
proteins separated either by standard chromatographic methods or by one- and two-dimensional …

Proteome analysis is concerned with the global changes in protein expression as visualized
most commonly by two‐dimensional gel electrophoresis and analyzed by mass …

Diurnal oscillations of gene expression controlled by the circadian clock and its connected
feeding rhythm enable organisms to coordinate their physiologies with daily environmental …

Upon DNA damage, a complex called the PIDDosome is formed and either signals NF‐κB
activation and thus cell survival or alternatively triggers caspase‐2 activation and apoptosis. …

Cul3 (Cullin3)-based E3 ubiquitin ligases recently emerged as critical regulators of mitosis.
In this study, we identify two mammalian BTB (Bric-a-brac–Tramtrack–Broad complex)-Kelch …