Virus-based cancer vaccines are nowadays considered an interesting approach in the field
of cancer immunotherapy, despite the observation that the majority of the immune responses …

These findings establish a novel technology that enhances oncolytic cancer immunotherapy
by capitalizing on pre-acquired immunity to pathogens to convert a weak antitumor immune …

Besides the isolation and identification of major histocompatibility complex I-restricted peptides
from the surface of cancer cells, one of the challenges is eliciting an effective antitumor …

Original research: Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc
PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor …

The approval of the first oncolytic virus for the treatment of metastatic melanoma and the
compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies …

The advent of nanomedicine has recently started to innovate the treatment of cardiovascular
diseases, in particular myocardial infarction. Although current approaches are very …

… Manlio Fusciello … Manlio Fusciello … Brown, Beatriz Martins, Manlio Fusciello, Erkko O.
Ylösmäki, Dario Greco, Anna S. Kreutzman, Satu Mustjoki, Barbara Szomolay, Vincenzo Cerullo; …

Identification of HLA class I ligands from the tumor surface (ligandome or immunopeptidome)
is essential for designing T-cell mediated cancer therapeutic approaches. However, the …

Malignant pleural mesothelioma (MPM) is an aggressive tumor with a poor prognosis. As
the available therapeutic options show a lack of efficacy, novel therapeutic strategies are …

Oncolytic Viruses (OVs) work through two main mechanisms of action: the direct lysis of the
virus-infected cancer cells and the release of tumor antigens as a result of the viral burst. In …