Importance Tumor-treating fields (TTFields) is an antimitotic treatment modality that
interferes with glioblastoma cell division and organelle assembly by delivering low-intensity …

Importance Clinical outcomes for glioblastoma remain poor. Treatment with immune
checkpoint blockade has shown benefits in many cancer types. To our knowledge, data from a …

Approximately 40–50% of glioblastomas (GBM) overexpress epidermal growth factor receptor
(EGFR). Erlotinib is a specific and potent EGFR tyrosine kinase inhibitor active against …

Metastasis, involving the spread of systemic cancer to the brain, results in neurologic
disability and death. Current treatments are largely palliative in nature; improved therapeutic …

Survivin is an anti-apoptotic protein that is highly expressed in many cancers, including
malignant gliomas. Preclinical studies established that the conjugated survivin peptide mimic …

The coordination of complex tumor processes requires cells to rapidly modify their
phenotype and is achieved by direct cell-cell communication through gap junction channels …

… ’s t-tests or Wilcoxon rank-sum tests, while categorical data were compared with Fisher’s exact
… To test for differences in cumulative incidences across cohorts, Gray’s tests were utilized. …

Glioblastoma is the most common adult malignant primary brain tumor. Despite the
advances in therapeutic options, survival of patients with glioblastoma remains dismal at 15–18 …

An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal
growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for …