Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model
W Lee, RC Reyes, MK Gottipati, K Lewis, M Lesort… - Neurobiology of …, 2013 - Elsevier
Huntington's disease (HD) causes preferential loss of a subset of neurons in the brain
although the huntingtin protein is expressed broadly in various neural cell types, including …
although the huntingtin protein is expressed broadly in various neural cell types, including …
TGFβ3 is neuroprotective and alleviates the neurotoxic response induced by aligned poly-l-lactic acid fibers on naïve and activated primary astrocytes
Following spinal cord injury, astrocytes at the site of injury become reactive and exhibit a
neurotoxic (A1) phenotype, which leads to neuronal death. In addition, the glial scar, which is …
neurotoxic (A1) phenotype, which leads to neuronal death. In addition, the glial scar, which is …
[HTML][HTML] Electrospun fiber scaffolds for engineering glial cell behavior to promote neural regeneration
… Manoj K. Gottipati … Conversely, a recent study by Gottipati et al. further characterized
astrocytic response to electrospun fibers by studying the expression of various reactive …
astrocytic response to electrospun fibers by studying the expression of various reactive …
Biomaterial approaches to modulate reactive astroglial response
Over several decades, biomaterial scientists have developed materials to spur axonal
regeneration and limit secondary injury and tested these materials within preclinical animal …
regeneration and limit secondary injury and tested these materials within preclinical animal …
Imaging of mitochondrial Ca2+ dynamics in astrocytes using cell-specific mitochondria-targeted GCaMP5G/6s: mitochondrial Ca2+ uptake and cytosolic Ca2+ …
Mitochondrial Ca 2+ plays a critical physiological role in cellular energy metabolism and
signaling, and its overload contributes to various pathological conditions including neuronal …
signaling, and its overload contributes to various pathological conditions including neuronal …
Chemically functionalized water-soluble single-walled carbon nanotubes modulate morpho-functional characteristics of astrocytes
We report the use of chemically functionalized water-soluble single-walled carbon nanotubes
(ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When …
(ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When …
Chemically functionalized single-walled carbon nanotube films modulate the morpho-functional and proliferative characteristics of astrocytes
We used single-walled carbon nanotube (CNT) films to modulate the morpho-functional and
proliferative characteristics of astrocytes. When plated on the CNT films of various …
proliferative characteristics of astrocytes. When plated on the CNT films of various …
Intraspinal TLR4 activation promotes iron storage but does not protect neurons or oligodendrocytes from progressive iron-mediated damage
Iron is essential for basic cellular functions but in excess is highly toxic. For this reason, free
iron and iron storage are controlled in the periphery by elaborate regulatory mechanisms. In …
iron and iron storage are controlled in the periphery by elaborate regulatory mechanisms. In …
[HTML][HTML] Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice
Humanized mice can be used to better understand how the human immune system responds
to central nervous system (CNS) injury and inflammation. The optimal parameters for using …
to central nervous system (CNS) injury and inflammation. The optimal parameters for using …
Chemically functionalized single-walled carbon nanotubes enhance the glutamate uptake characteristics of mouse cortical astrocytes
Using a radioactive glutamate uptake assay and immunolabeling, we report that single-walled
carbon nanotubes, chemically functionalized with polyethylene glycol (SWCNT-PEG), …
carbon nanotubes, chemically functionalized with polyethylene glycol (SWCNT-PEG), …