User profiles for Manuel M. Vicente

Manuel M Vicente

Hannover Medical School
Verified email at mh-hannover.de
Cited by 266

[HTML][HTML] Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

MM Vicente, E Leite-Gomes, SS Pinho - Trends in Immunology, 2023 - cell.com
Glycans cover the surfaces of all mammalian cells through a process called glycosylation.
Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory …

Altered IgG glycosylation at COVID‐19 diagnosis predicts disease severity

MM Vicente, I Alves, J Gaifem… - European journal of …, 2022 - Wiley Online Library
The nature of the immune responses associated with COVID‐19 pathogenesis and disease
severity, as well as the breadth of vaccine coverage and duration of immunity, is still unclear. …

[HTML][HTML] Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

MM Vicente, I Alves, Â Fernandes, AM Dias… - Cellular & Molecular …, 2023 - nature.com
T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs)
that recognize a variety of antigens. Glycosylation is a major posttranslational modification …

Composition of the immunoglobulin G glycome associates with the severity of COVID-19

…, A Skelin, J Gaifem, J Villar-Garcia, MM Vicente… - …, 2021 - academic.oup.com
A large variation in the severity of disease symptoms is one of the key open questions in
coronavirus disease 2019 (COVID-19) pandemics. The fact that only a small subset of people …

Glycans as shapers of tumour microenvironment: a sweet driver of T‐cell‐mediated anti‐tumour immune response

…, MC Silva, G Faria, CS Dantas, MM Vicente… - …, 2023 - Wiley Online Library
Essentially all cells are covered with a dense coat of different glycan structures/sugar chains,
giving rise to the so‐called glycocalyx. Changes in cellular glycosylation are a hallmark of …

[HTML][HTML] The off-targets of clustered regularly interspaced short palindromic repeats gene editing

MM Vicente, M Chaves-Ferreira, JMP Jorge… - Frontiers in Cell and …, 2021 - frontiersin.org
The repurposing of the CRISPR/Cas bacterial defense system against bacteriophages as
simple and flexible molecular tools has revolutionized the field of gene editing. These tools are …

Protein mannosylation as a diagnostic and prognostic biomarker of lupus nephritis: an unusual glycan neoepitope in systemic lupus erythematosus

…, MM Vicente, A Campar, M Thepaut… - Arthritis & …, 2021 - Wiley Online Library
Objective Changes in protein glycosylation are a hallmark of immune‐mediated diseases.
Glycans are master regulators of the inflammatory response and are important molecules in …

The role of glycosylation in inflammatory diseases

I Alves, MM Vicente, AM Dias, J Gaifem… - The Role of …, 2021 - Springer
The diversity of glycan presentation in a cell, tissue and organism is enormous, which reflects
the huge amount of important biological information encoded by the glycome which has …

[HTML][HTML] Toward the integrated marine debris observing system

…, I Macadam-Somer, T Mace, M Manuel… - Frontiers in marine …, 2019 - frontiersin.org
Plastics and other artificial materials pose new risks to health of the ocean. Anthropogenic
debris travels across large distances and is ubiquitous in the water and on the shorelines, yet, …

A CyclinB2-Cas9 fusion promotes the homology-directed repair of double-strand breaks

MM Vicente, A Mendes, M Cruz, JR Vicente… - bioRxiv, 2019 - biorxiv.org
The discovery of clustered regularly interspaced palindromic repeats (CRISPR), a defense
system against viruses found in bacteria, launched a new era in gene targeting. The key …