Synucleinopathies, which include multiple system atrophy (MSA), Parkinson’s disease,
Parkinson’s disease with dementia and dementia with Lewy bodies (DLB), are human …

Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in
Alzheimer’s disease. Here, we report the cryo–electron microscopy (cryo-EM) structures of …

A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative
diseases target their characteristic proteopathic lesions (α-synuclein, Tau, Aβ). To …

The ordered assembly of tau protein into abnormal filaments is a defining characteristic of
Alzheimer’s disease (AD) and other neurodegenerative disorders. It is not known if the …

Parkinson’s disease (PD) is the most common movement disorder, with resting tremor, rigidity,
bradykinesia and postural instability being major symptoms 1 . Neuropathologically, it is …

Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s,
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …

The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein
complexes called mTORC1 and mTORC2. Whereas mTORC1 is known to regulate cell and …

The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in
amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-…

The propagation of conformational strains by templated seeding is central to the prion
concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like …

Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies.
They develop neurodegeneration and abundant filamentous inclusions made of human …