User profiles for Manzar Hossain
 | Manzar HossainCold Spring Harbor Laboratory Verified email at cshl.edu Cited by 426 |
[PDF][PDF] Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication
The initiation of DNA replication involves cell cycle-dependent assembly and disassembly
of protein complexes, including the origin recognition complex (ORC) and CDC6 AAA + …
of protein complexes, including the origin recognition complex (ORC) and CDC6 AAA + …
Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication
M Hossain, B Stillman - Genes & development, 2012 - genesdev.cshlp.org
Like DNA replication, centrosomes are licensed to duplicate once per cell division cycle to
ensure genetic stability. In addition to regulating DNA replication, the Orc1 subunit of the …
ensure genetic stability. In addition to regulating DNA replication, the Orc1 subunit of the …
[HTML][HTML] Orc1 binding to mitotic chromosomes precedes spatial patterning during G1 phase and assembly of the origin recognition complex in human cells
Replication of eukaryotic chromosomes occurs once every cell division cycle in normal cells
and is a tightly controlled process that ensures complete genome duplication. The origin …
and is a tightly controlled process that ensures complete genome duplication. The origin …
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
E Tramentozzi, P Ferraro, M Hossain, B Stillman… - Cell Cycle, 2018 - Taylor & Francis
SAMHD1 is the major catabolic enzyme regulating the intracellular concentrations of DNA
precursors (dNTPs). The S-phase kinase CDK2-cyclinA phosphorylates SAMHD1 at Thr-592. …
precursors (dNTPs). The S-phase kinase CDK2-cyclinA phosphorylates SAMHD1 at Thr-592. …
Proteome Analysis Reveals a Large Merozoite Surface Protein-1 Associated Complex on the Plasmodium falciparum Merozoite Surface
…, S Singh, S Kanodia, MJ Hossain… - Journal of Proteome …, 2011 - ACS Publications
Plasmodium merozoite surface protein-1 (MSP-1) is an essential antigen for the merozoite
invasion of erythrocytes. A key challenge to the development of an effective malaria vaccine …
invasion of erythrocytes. A key challenge to the development of an effective malaria vaccine …
Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription
M Hossain, B Stillman - Elife, 2016 - elifesciences.org
10.7554/eLife.12785.001 Newly born cells either continue to proliferate or exit the cell
division cycle. This decision involves delaying expression of Cyclin E that promotes DNA …
division cycle. This decision involves delaying expression of Cyclin E that promotes DNA …
A role of falcipain-2, principal cysteine proteases of Plasmodium falciparum in merozoite egression
The process of merozoite release in Plasmodium falciparum involves rupture of the
parasitophorous vacuole membrane and erythrocyte plasma membrane. Through the use of …
parasitophorous vacuole membrane and erythrocyte plasma membrane. Through the use of …
Tudor domain proteins in protozoan parasites and characterization of Plasmodium falciparum tudor staphylococcal nuclease
MJ Hossain, R Korde, S Singh, A Mohmmed… - International journal for …, 2008 - Elsevier
RNA-binding proteins play key roles in post-transcriptional regulation of gene expression. In
eukaryotic cells, a multitude of RNA-binding proteins with several RNA-binding domains/…
eukaryotic cells, a multitude of RNA-binding proteins with several RNA-binding domains/…
Plasmodium falciparum Tudor Staphylococcal Nuclease interacting proteins suggest its role in nuclear as well as splicing processes
MJ Hossain, R Korde, PK Singh, S Kanodia, R Ranjan… - Gene, 2010 - Elsevier
Tudor Staphylococcal Nuclease (p100 or SND1), a member of the micronuclease family is a
multifunctional protein that plays a key role(s) in transcription and splicing processes in …
multifunctional protein that plays a key role(s) in transcription and splicing processes in …
[HTML][HTML] Organization of Plasmodium falciparum spliceosomal core complex and role of arginine methylation in its assembly
M Hossain, S Sharma, R Korde, S Kanodia, M Chugh… - Malaria Journal, 2013 - Springer
Background Splicing and alternate splicing are the two key biological processes that result
in the generation of diverse transcript and protein isoforms in Plasmodium falciparum as well …
in the generation of diverse transcript and protein isoforms in Plasmodium falciparum as well …