Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and chemical …

INTRODUCTION The mitochondrial adenosine triphosphate (ATP) synthase is the enzyme
responsible for the synthesis of more than 90% of the ATP produced by mammalian cells …

The study of enveloped animal viruses has greatly advanced our understanding of the general
properties of membrane fusion and of the specific pathways that viruses use to infect the …

Lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria is critical for
the assembly of their cell envelopes. LPS synthesized in the cytoplasmic leaflet of the inner …

Highlights • Single particle cryo-EM is now capable of determining ab initio atomic structures
of integral membrane proteins. • Production of high quality, biochemically stable proteins is …

Mitochondria take up Ca 2+ through the mitochondrial calcium uniporter complex to
regulate energy production, cytosolic Ca 2+ signalling and cell death 1 , 2 . In mammals, the …

INTRODUCTION Protein homeostasis in the endoplasmic reticulum (ER) is maintained by a
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …

Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric
plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads …

Type I CRISPR systems feature a sequential dsDNA target searching and degradation process,
by crRNA-displaying Cascade and nuclease-helicase fusion enzyme Cas3, respectively. …

Transient receptor potential (TRP) channels are polymodal signal detectors that respond to
a wide range of physical and chemical stimuli. Elucidating how these channels integrate and …