A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
The way in which cells adopt different morphologies is not fully understood. Cell shape could
be a continuous variable or restricted to a set of discrete forms. We developed quantitative …
be a continuous variable or restricted to a set of discrete forms. We developed quantitative …
[HTML][HTML] Microenvironmental heterogeneity parallels breast cancer progression: a histology–genomic integration analysis
…, H Sailem, FK Mardakheh, M Arias Garcia… - PLoS …, 2016 - journals.plos.org
Background The intra-tumor diversity of cancer cells is under intense investigation; however,
little is known about the heterogeneity of the tumor microenvironment that is key to cancer …
little is known about the heterogeneity of the tumor microenvironment that is key to cancer …
[HTML][HTML] Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells
Cancer cells feature a resting membrane potential (V m ) that is depolarized compared to
normal cells, and express active ionic conductances, which factor directly in their …
normal cells, and express active ionic conductances, which factor directly in their …
[HTML][HTML] RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer
In order to metastasise, triple negative breast cancer (TNBC) must make dynamic changes
in cell shape. The shape of all eukaryotic cells is regulated by Rho Guanine Nucleotide …
in cell shape. The shape of all eukaryotic cells is regulated by Rho Guanine Nucleotide …
[HTML][HTML] Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition
M Beykou, M Arias-Garcia, TI Roumeliotis… - Scientific data, 2022 - nature.com
When used in combination with hormone treatment, Palbociclib prolongs progression-free
survival of patients with hormone receptor positive breast cancer. Mechanistically, Palbociclib …
survival of patients with hormone receptor positive breast cancer. Mechanistically, Palbociclib …
Discovery of rare phenotypes in cellular images using weakly supervised deep learning
… Heba Sailem *1, Mar Arias–Garcia2, Chris Bakal2, Andrew Zisserman1, and Jens
Rittscher∗1 … Mar Arias–Garcia and Chris Bakal provided the data for this study. …
Rittscher∗1 … Mar Arias–Garcia and Chris Bakal provided the data for this study. …
Epithelial-Mesenchymal Plasticity is regulated by inflammatory signalling networks coupled to cell morphology
MA Garcia, Z Yin, TI Roumeliotis, F Butera, L Wang… - BioRxiv, 2019 - biorxiv.org
Morphology dictates how cells sense physical and soluble cues in their environment; thus
contributing to fate decisions. The differentiation of epithelial cells into mesenchymal forms, or …
contributing to fate decisions. The differentiation of epithelial cells into mesenchymal forms, or …
[HTML][HTML] Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis
M Sanchez-Alvarez, F Finger, MM Arias-Garcia… - PLoS …, 2014 - journals.plos.org
The function and capacity of the endoplasmic reticulum (ER) is determined by multiple
processes ranging from the local regulation of peptide translation, translocation, and folding, to …
processes ranging from the local regulation of peptide translation, translocation, and folding, to …
Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress
Reactive Oxygen Species (ROS) are a natural by-product of cellular growth and proliferation,
and are required for fundamental processes such as protein-folding and signal transduction…
and are required for fundamental processes such as protein-folding and signal transduction…
Membrane voltage fluctuations in human breast cancer cells
Cancer cells feature a resting membrane potential (V m ) that is depolarized compared to
normal cells, and express active ionic conductances, which factor directly in their …
normal cells, and express active ionic conductances, which factor directly in their …