A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

Z Yin, A Sadok, H Sailem, A McCarthy, X Xia, F Li… - Nature cell …, 2013 - nature.com
The way in which cells adopt different morphologies is not fully understood. Cell shape could
be a continuous variable or restricted to a set of discrete forms. We developed quantitative …

[HTML][HTML] Microenvironmental heterogeneity parallels breast cancer progression: a histology–genomic integration analysis

…, H Sailem, FK Mardakheh, M Arias Garcia… - PLoS …, 2016 - journals.plos.org
Background The intra-tumor diversity of cancer cells is under intense investigation; however,
little is known about the heterogeneity of the tumor microenvironment that is key to cancer …

[HTML][HTML] Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells

P Quicke, Y Sun, M Arias-Garcia, M Beykou… - Communications …, 2022 - nature.com
Cancer cells feature a resting membrane potential (V m ) that is depolarized compared to
normal cells, and express active ionic conductances, which factor directly in their …

[HTML][HTML] RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer

…, S Cooper, J Sero, V Bousgouni, M Arias-Garcia… - Scientific data, 2017 - nature.com
In order to metastasise, triple negative breast cancer (TNBC) must make dynamic changes
in cell shape. The shape of all eukaryotic cells is regulated by Rho Guanine Nucleotide …

[HTML][HTML] Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition

M Beykou, M Arias-Garcia, TI Roumeliotis… - Scientific data, 2022 - nature.com
When used in combination with hormone treatment, Palbociclib prolongs progression-free
survival of patients with hormone receptor positive breast cancer. Mechanistically, Palbociclib …

Discovery of rare phenotypes in cellular images using weakly supervised deep learning

H Sailem, M Arias-Garcia, C Bakal… - Proceedings of the …, 2017 - openaccess.thecvf.com
… Heba Sailem *1, Mar Arias–Garcia2, Chris Bakal2, Andrew Zisserman1, and Jens
Rittscher∗1 … Mar AriasGarcia and Chris Bakal provided the data for this study. …

Epithelial-Mesenchymal Plasticity is regulated by inflammatory signalling networks coupled to cell morphology

MA Garcia, Z Yin, TI Roumeliotis, F Butera, L Wang… - BioRxiv, 2019 - biorxiv.org
Morphology dictates how cells sense physical and soluble cues in their environment; thus
contributing to fate decisions. The differentiation of epithelial cells into mesenchymal forms, or …

[HTML][HTML] Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis

M Sanchez-Alvarez, F Finger, MM Arias-Garcia… - PLoS …, 2014 - journals.plos.org
The function and capacity of the endoplasmic reticulum (ER) is determined by multiple
processes ranging from the local regulation of peptide translation, translocation, and folding, to …

Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress

MA Garcia, MS Alvarez, H Sailem, V Bousgouni… - Molecular …, 2012 - pubs.rsc.org
Reactive Oxygen Species (ROS) are a natural by-product of cellular growth and proliferation,
and are required for fundamental processes such as protein-folding and signal transduction…

Membrane voltage fluctuations in human breast cancer cells

P Quicke, Y Sun, M Arias-Garcia, CD Acker… - bioRxiv, 2021 - biorxiv.org
Cancer cells feature a resting membrane potential (V m ) that is depolarized compared to
normal cells, and express active ionic conductances, which factor directly in their …