User profiles for Marc Baldus

Marc Baldus

Utrecht University, Bijvoet Center for Biomolecular Research
Verified email at uu.nl
Cited by 18049

Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR

…, OC Andronesi, D Riedel, M Baldus - Proceedings of the …, 2005 - National Acad Sciences
The 140-residue protein α-synuclein (AS) is able to form amyloid fibrils and as such is the
main component of protein inclusions involved in Parkinson's disease. We have investigated …

Cross polarization in the tilted frame: assignment and spectral simplification in heteronuclear spin systems

M Baldus, AT Petkova, J Herzfeld, RG Griffin - Molecular Physics, 1998 - Taylor & Francis
A frequency selective heteronuclear polarization transfer technique is introduced for rotating
solids. In this method, radiofrequency fields comparable with the frequency offsets are …

Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models

…, K Giller, S Becker, A Herzig, M Baldus… - The EMBO …, 2009 - embopress.org
The relation of α‐synuclein (αS) aggregation to Parkinson's disease (PD) has long been
recognized, but the mechanism of toxicity, the pathogenic species and its molecular properties …

Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR

…, MF Martin-Eauclaire, O Pongs, S Becker, M Baldus - Nature, 2006 - nature.com
The active site of potassium (K + ) channels catalyses the transport of K + ions across the
plasma membrane 1 —similar to the catalytic function of the active site of an enzyme—and is …

Backbone and Side‐Chain 13C and 15N Signal Assignments of the α‐Spectrin SH3 Domain by Magic Angle Spinning Solid‐State NMR at 17.6 Tesla

J Pauli, M Baldus, B van Rossum, H de Groot… - …, 2001 - Wiley Online Library
The backbone and side‐chain 13 C and 15 N signals of a solid 62‐residue (u‐ 13 C, 15 N)‐labelled
protein containing the α‐spectrin SH3 domain were assigned by two‐dimensional (…

Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: The power of native nanodiscs

…, TR Dafforn, M Baldus… - Proceedings of the …, 2014 - National Acad Sciences
A major obstacle in the study of membrane proteins is their solubilization in a stable and
active conformation when using detergents. Here, we explored a detergent-free approach to …

Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy

…, K Seidel, H Heise, HS Young, M Baldus - Journal of the …, 2005 - ACS Publications
It is shown that molecular structure and dynamics of a uniformly labeled membrane protein
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …

Efficient dynamic nuclear polarization at 800 MHz/527 GHz with trityl‐nitroxide biradicals

…, JL Zweier, M Rosay, M Baldus… - Angewandte Chemie …, 2015 - Wiley Online Library
Cross‐effect (CE) dynamic nuclear polarization (DNP) is a rapidly developing technique that
enhances the signal intensities in magic‐angle spinning (MAS) NMR spectra. We report CE …

Platinum‐Promoted Ga/Al2O3 as Highly Active, Selective, and Stable Catalyst for the Dehydrogenation of Propane

…, TWGM Verhoeven, EJ Koers, M Baldus… - Angewandte …, 2014 - Wiley Online Library
A novel catalyst material for the selective dehydrogenation of propane is presented. The
catalyst consists of 1000 ppm Pt, 3 wt % Ga, and 0.25 wt % K supported on alumina. We …

Structural constraints from proton-mediated rare-spin correlation spectroscopy in rotating solids

A Lange, S Luca, M Baldus - Journal of the American Chemical …, 2002 - ACS Publications
A novel solid-state NMR concept is introduced that allows for the detection of through-space
proton−proton contacts in high spectral resolution. The proposed method not only can be …