Amyloid β-peptide (Aβ) is a major fibrillar component of neuritic plaques in Alzheimer's
disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that …

A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates
that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic …

One of the primary regulators of maternofetal glucose transfer is the density of glucose
transporter proteins in the placenta. These transporters, members of the GLUT gene family of …

Serum amyloid A (SAA) is an acute-phase protein, the serum levels of which can increase up
to 1000-fold during inflammation. SAA has a pathogenic role in amyloid A-type amyloidosis…

Formaldehyde dehydrogenase (EC 1.2.1.1) is a widely occurring enzyme which catalyzes the
oxidation of S-hydroxymethylglutathione, formed from formaldehyde and glutathione, into S…

Clinical proteomics has yielded some early positive results—the identification of potential
disease biomarkers—indicating the promise for this analytical approach to improve the current …

Notch signaling is critically important for proper architecture of the vascular system, and
mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with …

The neuronal ceroid lipofuscinoses (NCLs) constitute a group of neurodegenerative storage
diseases characterized by progressive psychomotor retardation, blindness and premature …

CADASIL and CARASIL are hereditary small vessel diseases leading to vascular dementia.
CADASIL commonly begins with migraine followed by minor strokes in mid‐adulthood. …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
(CADASIL) is the most common hereditary subcortical vascular dementia. It is caused by …