The therapeutic management of severe radiation burns remains a challenging issue today.
Conventional surgical treatment including excision, skin autograft, or flap often fails to …

Fibrosis is the endpoint of many chronic inflammatory diseases and is defined by an abnormal
accumulation of extracellular matrix components. Despite its slow progression, it leads to …

Damage to vessels is one of the most common effects of therapeutic irradiation on normal
tissues. We undertook a study in patients treated with preoperative radiotherapy and …

About half of people with cancer are treated with radiation therapy; however, normal tissue
toxicity still remains a dose-limiting factor for this treatment. The skin response to ionizing …

Erythema was observed on the skin of the first patients treated with radiation therapy. It is in
particular to reduce this erythema, one feature of tissue inflammation, that prescribed dose to …

Mesenchymal stem cells (MSC), multipotent adult stem cells, feature the potential to
regenerate tissue damage and, in parallel, inhibit inflammation and fibrosis. MSC can be safely …

The management of proctitis in patients who have undergone very-high-dose conformal
radiotherapy is extremely challenging. The fibrosis-necrosis, fistulae, and hemorrhage induced …

… Marc Benderitter Marc Benderitter … Marie-Hélène Gaugler, Valérie Vereycken-Holler, Claire
Squiban, Marie Vandamme, Marie-Catherine Vozenin-Brotons, Marc Benderitter; Pravastatin …

Background Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local
recurrence and deaths resulting from breast cancer but it can lead to secondary effects due …

Significance: Targeted irradiation is an effective cancer therapy but damage inflicted to
normal tissues surrounding the tumor may cause severe complications. While certain …