The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …

Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal
domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered …

In response to stress, human cells coordinately downregulate transcription and translation
of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) …

Liquid–liquid phase separation is a key organizational principle in eukaryotic cells, on par
with intracellular membranes. It allows cells to concentrate specific proteins into condensates, …

Phosphatases, including phytases, play a major role in cell metabolism, phosphorus cycle,
biotechnology, and pathogenic processes. Nevertheless, their discovery by functional …

We talk to Prashant Rawat and Marc Boehning, collaborators and co-first authors of "Stress-induced
nuclear condensation of NELF drives global transcriptional downregulation" (this …

A hallmark of the disease state following severe burn injury is decreased liver function, which
results in gross metabolic derangements that compromise patient survival. The underlying …

After a severe burn, the liver plays a pivotal role by modulating inflammatory processes,
metabolic pathways, immune functions, and the acute phase response. Therefore, liver integrity …

Severe burn injury results in liver dysfunction and damage, with subsequent metabolic
derangements contributing to patient morbidity and mortality. On a cellular level, significant …