User profiles for Marc D. Normandin
 | Marc D. Normandin, Ph.D.Associate Professor of Radiology, Harvard Medical School; Associate Investigator in Physics … Verified email at mgh.harvard.edu Cited by 4659 |
Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue
Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding
patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as T807)…
patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as T807)…
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study
Endocannabinoids and their attending cannabinoid type 1 (CB 1) receptor have been implicated
in animal models of post-traumatic stress disorder (PTSD). However, their specific role …
in animal models of post-traumatic stress disorder (PTSD). However, their specific role …
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
…, DM Rentz, G El Fakhri, MD Normandin… - Science translational …, 2021 - science.org
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU increases, …
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU increases, …
Rapid changes in cannabinoid 1 receptor availability in cannabis-dependent male subjects after abstinence from cannabis
…, A Neumeister, B Pittman, MD Normandin… - Biological psychiatry …, 2016 - Elsevier
Background The widespread use of cannabis, the increasing legalization of “medical”
cannabis, the increasing potency of cannabis, and the growing recreational use of synthetic …
cannabis, the increasing potency of cannabis, and the growing recreational use of synthetic …
Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies
M Marquié, MD Normandin, AC Meltzer… - Annals of …, 2017 - Wiley Online Library
Objective Recent studies have shown that positron emission tomography (PET) tracer AV‐1451
exhibits high binding affinity for paired helical filament (PHF)‐tau pathology in …
exhibits high binding affinity for paired helical filament (PHF)‐tau pathology in …
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography
…, R Killiany, G El Fakhri, MD Normandin… - Science translational …, 2021 - science.org
Advances in molecular positron emission tomography (PET) have enabled anatomic
tracking of brain pathology in longitudinal studies of normal aging and dementia, including …
tracking of brain pathology in longitudinal studies of normal aging and dementia, including …
Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI
…, C Catana, MD Normandin… - Proceedings of the …, 2013 - National Acad Sciences
This study employed simultaneous neuroimaging with positron emission tomography (PET)
and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between …
and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between …
In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET
MD Normandin, KF Petersen, YS Ding… - Journal of nuclear …, 2012 - Soc Nuclear Med
The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …
[HTML][HTML] Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue
[F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered
for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic …
for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic …
Striatal dopamine transporter availability in unmedicated bipolar disorder
…, QH Zheng, GD Hutchins, MD Normandin… - Bipolar …, 2011 - Wiley Online Library
… Our BPD subjects were a balanced mix of BPD-D and BPD-E; we found no evidence that
striatal DAT binding was different between the mood states. The five subjects in the Amsterdam …
striatal DAT binding was different between the mood states. The five subjects in the Amsterdam …