Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
Clonal hematopoiesis (CH) is frequent in cancer patients and associated with increased risk
of therapy related myeloid neoplasms (tMN). To define the relationship between CH, …
of therapy related myeloid neoplasms (tMN). To define the relationship between CH, …
Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making
Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …
impediments to the adoption of precision medicine in patients with prostate cancer. To …
Germline variants identified in patients with early-onset renal cell carcinoma referred for germline genetic testing
Background Despite guidelines recommending genetic counseling for patients with early-onset
renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations …
renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations …
Chronic risk assessment of exposure to volatile organic compounds in the atmosphere near the largest Mediterranean industrial site
This study focuses on characterising the risk of exposure to volatile organic compounds (VOCs)
by means of inhalation in people living in the vicinity of the largest chemical production …
by means of inhalation in people living in the vicinity of the largest chemical production …
Risk assessment related to atmospheric polycyclic aromatic hydrocarbons in gas and particle phases near industrial sites
N Ramírez, A Cuadras, E Rovira… - Environmental health …, 2011 - ehp.niehs.nih.gov
Background: Inhalation is one of the main means of human exposure to polycyclic aromatic
hydrocarbons (PAHs) because of their ubiquitous presence in the atmosphere. However, …
hydrocarbons (PAHs) because of their ubiquitous presence in the atmosphere. However, …
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes
…, FJ Bravo, TP Foster, M Bosch-Marce… - Science translational …, 2014 - science.org
Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing
challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals …
challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals …
[HTML][HTML] A framework for ensemble modelling of climate change impacts on lakes worldwide: the ISIMIP Lake Sector
…, RI Woolway, L Grant, E Jennings… - Geoscientific Model …, 2022 - gmd.copernicus.org
Empirical evidence demonstrates that lakes and reservoirs are warming across the globe.
Consequently, there is an increased need to project future changes in lake thermal structure …
Consequently, there is an increased need to project future changes in lake thermal structure …
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …
identification of genomic alterations in genes and pathways that can be targeted …
Localized algal blooms induced by river inflows in a canyon type reservoir
… We used the parameters described in Robson and Hamilton (2004) for cyanobacteria (genus:
Microcystis) as input parameters used in the water quality model CAEDYM. For further …
Microcystis) as input parameters used in the water quality model CAEDYM. For further …
Cancer therapy shapes the fitness landscape of clonal hematopoiesis
Acquired mutations are pervasive across normal tissues. However, understanding of the
processes that drive transformation of certain clones to cancer is limited. Here we study this …
processes that drive transformation of certain clones to cancer is limited. Here we study this …