Oncologic therapy shapes the fitness landscape of clonal hematopoiesis

…, JS Medina, N Farnoud, D Glodzik, S Li, ME Robson… - BioRxiv, 2019 - biorxiv.org
Clonal hematopoiesis (CH) is frequent in cancer patients and associated with increased risk
of therapy related myeloid neoplasms (tMN). To define the relationship between CH, …

Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making

…, D Chakravarty, HA Vargas, ME Robson… - JCO precision …, 2017 - ascopubs.org
Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …

Germline variants identified in patients with early-onset renal cell carcinoma referred for germline genetic testing

…, DR Feldman, ZK Stadler, ME Robson… - European urology …, 2021 - Elsevier
Background Despite guidelines recommending genetic counseling for patients with early-onset
renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations …

Chronic risk assessment of exposure to volatile organic compounds in the atmosphere near the largest Mediterranean industrial site

N Ramírez, A Cuadras, E Rovira, F Borrull… - Environment …, 2012 - Elsevier
This study focuses on characterising the risk of exposure to volatile organic compounds (VOCs)
by means of inhalation in people living in the vicinity of the largest chemical production …

Risk assessment related to atmospheric polycyclic aromatic hydrocarbons in gas and particle phases near industrial sites

N Ramírez, A Cuadras, E Rovira… - Environmental health …, 2011 - ehp.niehs.nih.gov
Background: Inhalation is one of the main means of human exposure to polycyclic aromatic
hydrocarbons (PAHs) because of their ubiquitous presence in the atmosphere. However, …

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

…, FJ Bravo, TP Foster, M Bosch-Marce… - Science translational …, 2014 - science.org
Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing
challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals …

[HTML][HTML] A framework for ensemble modelling of climate change impacts on lakes worldwide: the ISIMIP Lake Sector

…, RI Woolway, L Grant, E Jennings… - Geoscientific Model …, 2022 - gmd.copernicus.org
Empirical evidence demonstrates that lakes and reservoirs are warming across the globe.
Consequently, there is an increased need to project future changes in lake thermal structure …

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

…, LB Saltz, HI Scher, PJ Sabbatini, ME Robson… - Nature medicine, 2017 - nature.com
Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …

Localized algal blooms induced by river inflows in a canyon type reservoir

J Vidal, R Marcé, T Serra, J Colomer, F Rueda… - Aquatic sciences, 2012 - Springer
… We used the parameters described in Robson and Hamilton (2004) for cyanobacteria (genus:
Microcystis) as input parameters used in the water quality model CAEDYM. For further …

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

…, N Farnoud, D Glodzik, S Li, ME Robson… - Nature …, 2020 - nature.com
Acquired mutations are pervasive across normal tissues. However, understanding of the
processes that drive transformation of certain clones to cancer is limited. Here we study this …